An 86th minute blunder by Olympique Lyon goalkeeper, Anthony Lopes, handed Benfica Lisbon a late goal for a 2-1 victory on Wednesday.
The result threw the UEFA Champions League Group G wide open.
Pizzi scored the winner after Lopes inexplicably threw the ball straight into the player’s path.
He then had no problem firing in from 25 metres for their first win in this season’s competition.
Rafa Silva had grabbed a fourth minute lead for the hosts but his injury a little later deprived Benfica of their main attacking threat.
There was little in terms of attacks from the visitors under new coach, Rudi Garcia, until Memphis Depay volleyed in the equaliser at the far post in the 70th minute.
Benfica hit the post in the 85th minute but were gifted the winner by Lopes a little later.
Benfica climb to three points, one behind Lyon and Zenit St Petersburg.
RB Leipzig, who defeated Zenit 2-1 earlier on Wednesday, are top on six points.